Basic Science Award Recipients

The ASSH Research Management Committee reviews all research grant submissions and submits its recommendations to the ASSH Council. Primary funding for ASSH basic science grants comes from the American Foundation for Surgery of the Hand. Funding is also provided by gifts restricted to the American Society for Surgery of the Hand through the Orthopaedic Research and Education Foundation (OREF). Learn more about applying for a Basic Science Research Grant.

2012

2011

Molecular mechanisms of contracture formation in neonatal brachial plexus injury
Roger Cornwall, MD

Light Activated Stent for Rapid Microvascular Anastomosis
Prabhu SenthilKumar, MD

Examination of the Role of Canonical Wnt Signaling in Impaired Fracture Healing in Older Versus Younger Mice
Alison Kitay, MD

Immediate restoration of Transected Peripheral Nerves with Polyethylene Glycol and Methylene Blue
Jonathan Winograd, MD

An Evaluation of Inflammation, Histology, and Function in Nerve Regeneration
Peter Tang, MD

Smad3 Regulation of Tendon Development and Gene Expression
Mohana Amirtharajah, MD

Anatomy and Biomechanics of the Forearm Interosseous Membrane
Leela Farr, MD

2010
The Role of Aging in Macrophage Recruitment and Activation Following Nerve Injury
Zhongyu John Li, MD, Jonathan Barnwell, MD

Comparative efficacy of autologous blood and platelet rich plasma in treating tendinopathy
James Calandruccio, MD

The Role of Rac1 GTPase in human Mesenchymal Stem Cell tenogenesis
Rowena McBeath, MD

Scaphotrapeziotrapezoid arthritis and carpal instability
Robin Neil Kamal, MD

Intrinsic Tendon Repair Requires the Recycling of Tendon Collagen Segments
John Ingraham, MD, H. Paul Erlich, PhD

Acellular nerve allografts in long nerve injury gaps
Phillip Johnson, MD, Susan MacKinnon, MD

2009
Erythropoietin for Neuroregeneration
John C. Elfar, MD; Richard I. Burton, MD

Utilization of Computed Tomography to evaluate the mechanics of the first CMC joint during dynamic loading
Christopher J. Got, MD; Arnold-Peter C. Weiss, MD; Joseph J. Crisco, PhD

Bioactive sutures for tendon repair: Efficacy of delivering stem cells in vivo
Jeffrey Yao, MD; Robert Lane Smith, PhD

2008
The role of the fracture-induced hemarthrosis in the formation of posttraumatic joint contractures
Kevin A. Hildebrand, MD; with Michael J. Monument, MD
 
A Comparison of the Performance of Chronically vs. Freshly Denervated Autograft in Nerve Repair
Jonathan E. Isaacs, MD; with Richard Costanza, MD and Satya Mallu, MD
 
Dupuytren's Disease is Putatively Caused by Actomyosin Cell Contractility
Howard Levinson, MD; with L. Scott Levin, MD and Salvatore V. Pizzo, MD, PhD

The effect of increased age on Schwann cell response to nerve injury
Zhongyu Li, MD, PhD; with Peter J. Apel, MD and Carolanne E. Milligan, PhD

The Effects of Controlled Release GDNF on Motor Nerve Regeneration
Amy Moore, MD; with Greg Borschel, MD; Susan Mackinnon, MD and Shelly Sakiyama-Elbert, PhD

Isometric motor force testing validation in a rabbit sciatic nerve injury model
Alexander Y. Shin, MD; with Guilherme Giusti, MD; Allen T. Bishop, MD; Brian A. Crum, MD and Robert J. Spinner, MD

2007
Enhanced Axonal Elongation in Nerve Gaps by Anisotropic GDNF Delivery
Kacey G. Marra, PhD; with W.P. Andrew Lee, MD, FACS; Douglas Weber, PhD 

The impact of Smad3 loss of function on TGF-beta signaling and the resultant scarring and adhesion formation during tendon healing
Warren C. Hammert, MD; with Regis J. O’Keefe, MD, PhD; Hani Awad, PhD; Evan Katzel 

Does Duration of Cold Ischaemia Following Tissue Harvest Affect the Cellular Viability of Epiphyseal Plates?
Martin I. Boyer, MD 

The Effect of Age and IGF-1 on Neurotrophin Expression After Nerve Repair
Zhongyu Li, MD, PhD; with L. Andrew Koman, MD; Peter Apel, MD  

2006
In vivo Kinematics of the Forearm
Neal C. Chen, MD; James Herndon, MD; Jesse Jupiter, MD and Guoan Li, PhD
 
Altered Myelination With Compression Neuropathies: The Role of Schwann Cell Mechanotransduction
Ranjan Gupta, MD; Laura S. Rummler, MS, PhD ABD 

Overcoming Skin Immunogenicity in Composite Tissue Transplantation
Mario G. Solari, MD; W.P. Andrew Lee, MD; Kia McClean, MD; Justin Sacks, MD; Elaine Horibe, MD; Jignesh Unadkat, MD and Maryam Felili-Hariri PhD 

Botulinum Toxin in the Prevention of Brachial Plexus Birth Palsy-Associated Shoulder Deformity
Zhongyu Li , MD, PhD; Jianjun Ma MD, PhD 

The Effect of Extensor Pollicis Longus Relocation on Thumb Extension:  A Biomechanical Analysis
Ethan R. Wiesler, MD; George D. Chloros, MD and Gary G. Poehling, MD
 
2005
Tolerogenic Dendritic Cells and Induction of Donor Antigen-Specific Tolerance to Vascularized Skin Allograft
Maryam Feili Hariri, PhD, W.P. Andrew Lee, MD

Cryopreservation of Composite Tissue Transplants
Brian Rinker, MD, Xiangdong Cui, MD, MSci; Betsy F. Fink, B.S., RLATG 

Simultaneous Blockade of Multiple Costimulatory Pathways for Nerve Allograft Regeneration
Thomas H. Tung, MD, Susan E. Mackinnon, MD; T. Mohanakuma, PhD 

Validation of MRI Based Models for Evaluating In vivo Joint Contacts Pressures
Kenneth J. Fischer, PhD, E. Bruce Toby, MD; Terence E. McIff, PhD; Mehmet Bilgen, PhD 

Scarless Flexor Tendon Wound Healing: Tissue Engineering of Intrasynovial Tendon Grafts
James Chang, MD, Alphonsus Chong, MD 

2004
Effects of centrally-and peripherally expressed Glial-derived neurotrophic factor on nerve regeneration in a novel transgenic mouse model
Terence M. Myckatyn, MD, Susan E. Mackinnon, MD, Alecander Parsadanian, MD

Gene therapy in peripheral nerve repair: can nerve conduits deliver a viral vector to the Schwann cell?
Matthew M. Tomaino, MD, Michael Leit, MD, MS, Nicholas A. Smerlis, MD 

Photochemical tissue bonding: a nanosuture approach to vascular repair
Jonathan M. Minograd, MD 

Potential of  mesenchymal stem cells from old donors to engineer neocartilage in vivo
Mark A. Randolph, MAS, John M. Mesa, MD, Jason Burdick, PhD, Michael J. Jaremchuk, MD 

Tolerance inducing strategy in hand allograft transplantation in non-human primates
Maria Siemionow, MD, Aleksandra Klimczak, PhD 

2003
Factors Affecting Kinematics of Radial Head Prostheses
Mark E. Baratz, MD, Mark Cohen, MD, Karol Galik, PhD, Mark Miller, PhD, Christopher Schmidt, MD
 
Dorsoventral Patterning in the Vertabrate Limb
Aaron Daluiski, MD, Lee Niswander, PhD
 
Tissue-Engineered Conduits for Peripheral Nerve Regeneration
Kacey Marra, MD, Jennifer M. Bennett, BS, J. Peter Rubin, MD
 
Tissue Engineered Cartilage Using Old Auricular Chondrocytes for Upper Extremity Arthroplasty
John Mesa, MD, Kristi Anseth, PhD, Mark A. Randolph, MAS, Andrew L. Warshaw, MD, Michael J. Yaremchuk, MD, MAS

Determinants of Motor Neuron Pathway Specificity
Christoper Nichols, MD, Michael J. Brenner, MD, Richard A. Chole, MD, Richard H. Gelberman, MD, Susan E. Mackinnon, MD,  Ph.D.J., Clinton Walker, MD

Improving Adherence Qualities of Transplanted Chondrocytes
Christian Weinand, MD, Larry J. Bonassar, PhD,  Thomas J. Gill, MD, Mark A. Randolph, M.A.S., Harry L. Rubash, MD

2002
Tissue Engineering Cartilage Using Bone Marrow Cells For Upper Extremity Arthroplasty
John M. Mesa, MD, Michael J. Yaremchuk, MD, Mark A. Randolph, MD, Maria C. Martinez, MD
 
Stacked End-to-Side Nerve Repairs for Complex Nerve Injuries
Michael J. Brenner, MD
 
Tolerance and Immunosupression in Hand and Limb Transplantation
Thomas H. Tung, MD, Susan E. Mackinnon, MD, T. Mohanakumar, PhD
 
Evaluation of a Tissue Engineered Material for Flexor Tendon Grafting in a Rabbit Model
Lisa J. Gould, MD, PhD
 
Neural Stem Cell Transplantation Enhances Peripheral Nerve Regeneration
T. Shane Johnson , MD, Jonathan M. Winograd, MD, Mark A. Randolph, MD
 
Effects of iNOS Inhibitor on Motor Functional Recovery Following Mechanical Injury of Peripheral Nerve
Long-En Chen, MD, PhD, Richard D. Goldner, MD
 
2001
Limb Transplantation Without Chronic Immunosuppression: Can Mixed Chimerism Induce Tolerance?
Shehan P. Hettiaratchy, MA, FRCS, Christene Huang, PhD, Mark A. Randolph, MAS, Francois Petit, MD, David W. Mathes, MD, Jamal A. Nazzal, MD, Eirik Svennevik, MD
 
Transplantation of Limb Allografts Without Chronic Immunosuppression:  Inducing Tolerance to the Cutaneous Tissue
Francois Petit, MD, Mark A. Randolph, MAS, Shehan P. Hettiaratchy, MD, David W. Mathes, MD, Jamal A. Nazzal, MD, Eirik Svennevik, MD
 
Static and Functional Stability of the Wrist Joint: An In Vitro and an In Vivo Study
Amit Gupta, MD, Tuna Ozyurekoglu, MD, Michael J. Voor, PhD, Vasudeva G. Iyer, MD
 
Prevention of Experimentally Induced Osteonecrosis by Soluble Angiogenic Factors
Young W. Kwon, MD, PhD, David M. Kalainov, MD
 
Bridging versus Non-bridging External Fixation of Distal Radius Fractures:  A Measure of Structural Rigidity in an Unstable Fracture Model
William F. Sims, MD, Thomas Trumble, MD
 
An In Vitro Biomechanical Evaluation of ‘Smart Suture’ for Flexor Tendon Repair
Keikhosrow Firoozbakshs, PhD, Moheb S. Moneim, MD, Andrew J. Veitch, MD, Kenna Larsen, BA
 
2000
Cold Preservation of Nerve Allografts and Immunosuppression with FK506 in Mice
Aaron G. Grand, MD, Susan E. Mackinnon, MD
 
Immortalized Dupuytren’s Cells:  A Novel Study Model
Douglas C. Ross, MD, Jeffrey Howard, PhD, Robert M. McFarlane, MD, FRCSC, FACS, Bing Siang Gan, MD, PhD, FRCSC
 
VEGF Promotion of Neoangiogenesis in conventional Nerve Grafts
Saichol Wongtrakul, MD, Allen T. Bishop, MD
 
Preserving the Structure and Function of Denervated Skeletal Muscle by Enteric Neuron Transplantation
Joel S. Solomon, MD, David T. Netscher, MD
 
1999 Functional Integration of Vascularized Musculoskeletal Tissue Allografts in Miniature Swine
David W. Mathes, MD, W.P. Andrew Lee, MD
 
A Biomechanical Evaluation of Anatomic Distal Radioulnar Joint Reconstruction Techniques
James M. Boler, MD, D.G. Murray, MD
 
The Use of Growth Factor and Gene Therapy for Denervated Muscle
Charles S. Day, MD, Johnny Huard, PhD, Matthew M. Tomaino, MD
 
Cytokine Manipulation of Explanted Dupuytren’s Affected Human Palmar Fascia
Phillip C. Kierney, MD, Martin C. Robson, MD
 
Tensile Strength of Healing Peripheral Nerve
Douglas C. Ross, MD, FRCSC, Claire Temple, MD
 
Keratinocyte-Seeded Three-Dimensional Hyaluron Matrix Bio-Composite Autograft
Min Hu, MD, Vincent R. Hentz, MD
 
Using Intact Nerve to Bridge Peripheral Nerve Defects: An Alternative to the Use of Nerve Grafts
Wren V. McAllister, BS, BA, Thomas Trumble, MD